Peyronie's disease: causes, symptoms, and treatment options

When dealing with Peyronie's disease, a condition where scar tissue builds up inside the penis, causing curvature and pain during erections. Also known as penile fibrosis, it typically appears in men over 40 and can affect confidence and sexual function.

The core issue is a fibrous plaque, a dense buildup of collagen that forms on the tunica albuginea that disrupts normal elasticity. As the plaque hardens, the penis bends—a condition called penile curvature, the visible bend that occurs during an erection. This curvature often leads to erectile dysfunction, difficulty achieving or maintaining an erection sufficient for intercourse. Researchers link plaque formation to micro‑trauma, genetic factors, and abnormal wound healing. Lifestyle factors such as smoking or uncontrolled diabetes can worsen the scar‑tissue response. Understanding these connections helps you see why early diagnosis and targeted therapy matter.

One of the most talked‑about treatments is collagenase (Xiaflex), an enzyme injection that softens and breaks down the plaque. By degrading the collagen fibers, collagenase can reduce curvature without surgery. Non‑surgical approaches also include penile traction devices, low‑intensity shockwave therapy, and oral supplements aimed at reducing inflammation. When curvature exceeds 30–45 degrees or causes severe pain, surgical correction—such as plaque incision or penile implant—might be recommended. Each option carries its own risk‑benefit profile, so shared decision‑making with a urologist is key.

If you’re looking for clear, actionable information on Peyronie's disease, you’re in the right spot. Below you’ll find a curated selection of articles that dive into medication comparisons, safe online purchasing of generic drugs, and practical tips for managing related conditions. Whether you’re curious about treatment costs, side‑effect profiles, or how to talk to your doctor, these resources break down the details in plain language. Scroll on to explore the full collection and get the guidance you need to take the next step confidently.